GB Sciences Co-Authors a Peer-Reviewed Article Showing that Heart Failure Can Be Mitigated, and Reversed, by Orally Administered Drugs Targeting a Cellular Cannabinoid Receptor
Pioneering new scientific research in the publication, Channels, explains the promise of targeting the ionotropic cannabinoid receptor TRPV1, for the treatment and reversal of heart failure.
LAS VEGAS, Nov. 27, 2018 /PRNewswire/ -- GB Sciences, Inc. (GBLX) is pleased to announce the publication of a research article co-authored by GB Sciences and key collaborators in the peer-reviewed journal Channels, which explains the potential medical benefits of using cannabinoid receptor-targeting therapies for the treatment of heart disease. GB Sciences' own Chief Science Officer, Dr. Andrea Small-Howard, joins co-authors including University of Hawaii faculty member and President of Makai Biotechnology, LLC, Dr. Alexander Stokes, and researchers from the University of Kyoto, Japan. The link to the article as published in PubMed, the notable government source for medical studies, is found at https://www.ncbi.nlm.nih.gov/pubmed/30424709.
"People are becoming more aware that cannabinoid-based therapies can have significant medical benefits for patients, and this research study brings attention to the potential life-saving applications of cannabinoids for the treatment of heart conditions through the manipulation of specific-cannabinoid sensitive receptors," explains Dr. Andrea Small-Howard. "Our study highlights the involvement of the cannabinoid-sensitive ion channel, TRPV1, which is a newly-discovered component of signaling systems in the falling heart but it role is pivotal. Critically, our study shows, for the first time, effective reversal and remediation of this pathology with long-term administration of the drugs."
"TRPV1 is a relatively newly recognized part of the endocannabinoid system and has previously been most studied as a pain receptor", explains Dr. Alexander Stokes. "TRPV1 receptors are abundant in the heart, and our data show that if we inhibit its function with promising orally-available drugs, we can effect an exciting rescue and reversal of failing heart pathology."
In December of 2016, GB Sciences licensed patents on methods for the treatment of cardiac hypertrophy and associated pathologies through regulation of the cannabinoid receptor, TRPV1, from Dr. Stokes of Makai Biotechnology. GB remains committed to cannabis-based therapies for heart disease, as demonstrated by their filing original patent applications on the use of myrcene-based complex mixtures for heart disease in May of 2017 and another patent application on cannabinoid and terpenoid-based complex mixtures for the treatment of heart disease through manipulation of cannabis-receptors in May of 2018.
John Poss, CEO of GB Sciences says, "Heart disease is still the leading global cause of death, and cannabinoid-based therapeutics are a promising new option for its treatment. At GB Sciences, we are committed to broadening the scope of scientific research using novel applications of cannabinoid therapies and rigorously demonstrating their effectiveness."
About Makai Biotechnology, LLC
Makai Biotechnology, LLC is a Hawaii-based cardiovascular therapy company established by Dr. Alexander J. Stokes, Assistant Professor at the University of Hawaii, John A Burns School of Medicine. Makai Biotechnology is developing novel therapies for the treatment of heart failure. A novel ion channel target has been identified that modulates heart disease. Under the direction of Dr. Alexander Stokes, Makai Biotechnology has validated multiple effective compounds that regulate this target. Makai Biotechnology plans to establish alliances with major pharmaceutical companies to develop and test compounds from pre-clinical through phase II human clinical trials.
About Chaminade University
Located in the international city of Honolulu on the island of O`ahu, Chaminade is regarded for its remarkably diverse student body–students come from the Hawai`i, the mainland U.S., the Pacific region, and beyond. Class sizes are small, with a low student-to-faculty ratio. Here, students develop professionally through service learning projects, research and internship experiences, and leadership and community networking opportunities. At Chaminade, students receive a personalized education that prepares them for an ever-changing future.
About GB Sciences, Inc.
GB Sciences, Inc. (GBLX) is a diverse cannabis company, focused on standardized cultivation and production methods; as well as biopharmaceutical research and development. The Company's goal is creating safe, standardized, pharmaceutical-grade, cannabinoid therapies that target a variety of medical conditions. To learn more about GB Sciences, Inc., go to: http://gbsciences.com.
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